{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"eksosomer-i-nanomedicin","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/da\/exosomes-in-nanomedicine\/","title":{"rendered":"Exosomer i nanomedicin"},"content":{"rendered":"

Den ber\u00f8mte f\u00e6tter.<\/strong><\/p>\n

Mesemrynale stamceller er, som et potentielt terapeutisk v\u00e6rkt\u00f8j, i \u00f8jeblikket en stjerne inden for det kliniske felt. Isolerede celler klassificeres imidlertid som biomedicin og er som s\u00e5dan underlagt mange komplekse regler. Vi er alle enige om, at mere medicin i vores kroppe og mere papirarbejde p\u00e5 vores skriveborde ikke n\u00f8dvendigvis er det, vi \u00f8nsker at se mere af i verden. Hvilket peger p\u00e5 behovet for en alternativ cellefri behandling.<\/p>\n

Genbrug er den nye sexede.<\/strong><\/p>\n

Ordsprog siger Ingen smerte, ingen gevinst<\/em>...men at undg\u00e5 yderligere medicinering (i 5 dage f\u00f8r indsamling af stamceller fra blodet), der flytter celler fra knoglemarven til blodbanen, men ogs\u00e5 medf\u00f8rer influenzalignende symptomer, eller (under bed\u00f8velse) at f\u00e5 indsat en n\u00e5l i dit bagerste b\u00e6kkenben, virker som en stor gevinst for os. En meget rig kilde til mesenkymale stamceller med en sammenlignelig lav indsamlingsinvasivitet er t\u00e6ttere p\u00e5, end vi tror.<\/p>\n

Det er kroppens b\u00e6redygtige energireserve \u2013 fedtv\u00e6vet, som nu (som et biprodukt af fedtsugninger) bliver behandlet som bioaffald.<\/p>\n

Selv den mindste vesikel kan \u00e6ndre fremtidens gang.<\/strong><\/p>\n

Fedtv\u00e6v er et heterogent v\u00e6v, der kan opdeles i to fraktioner: adipocytter (fedtceller) og den stromale vaskul\u00e6re fraktion. Sidstn\u00e6vnte best\u00e5r derefter af den ekstracellul\u00e6re matrix, en samling af forskellige celler (som lymfocytter, monocytter, fibroblaster, stamceller) og frigivet som en mediator af intercellul\u00e6r kommunikation: sekretomet, best\u00e5ende af proteiner (s\u00e5som v\u00e6kstfaktorer og hormoner) og vesikler \u2013 eksosomer.<\/p>\n

Nyere unders\u00f8gelser viste, at den regenerative kapacitet (i organer, hjerne, nethinde og ledbrusk) af selve sekretomet, uden fedt-afledte stamceller eller andre celler, er sammenlignelig med den regenerative kapacitet af hele lipoaspiratet, hvilket afsl\u00f8rer, at exosomer er vigtige transport\u00f8rer af biologiske peptider, miRNA, kemokiner, cytokiner, enzymer, immunregulerende, trofiske og v\u00e6kstfaktorer.<\/p>\n

Vores dyrebare..<\/strong><\/p>\n

En exosome er en lille, enkelt-membran\u00f8s, udskilt organel med samme topologi som sin modercelle. Den har potentiale til at tiltr\u00e6kke celler og stimulere differentiering, proliferation og vaskularisering, som er essentielle i v\u00e6vsregenerering.<\/p>\n

Heldigvis er det meste af det, vi er lavet af.<\/p>\n

Hvad f\u00e5r jeg ud af det, en sund person i min bedste alder?<\/strong><\/p>\n

Vores st\u00f8rste organ \u2013 huden \u2013 gennemg\u00e5r en konstant modningsproces, mister sin vitalitet, mens vi taler, eller, som et andet eksempel, trods ung alder viser misfarvninger eller (efter akne, ulykker eller kirurgiske indgreb) ar eller s\u00e5r, der er sv\u00e6re at hele.<\/p>\n

..og vores vision.<\/strong><\/p>\n

Eksosomernes regenerative aktivitet, samt protokoller til at isolere dem, er i \u00f8jeblikket under omfattende (tids- og omkostningskr\u00e6vende) unders\u00f8gelse og giver lovende resultater.<\/p>\n

Til dato er der dog ingen medicinsk enhed tilg\u00e6ngelig til at isolere og evaluere (ved brug af multi-omics) antallet og dimensionen af \u200b\u200bexosomer og unders\u00f8ge oprindelsen af \u200b\u200bdisse ekstracellul\u00e6re vesikler (baseret p\u00e5 en antigenanalyse), for at kunne anvende dem i velkontrollerede, cellefrie, overkommelige terapier, hvilket var inspirationen til at g\u00f8re det til vores fokus.<\/p>\n

Derfor ser vi der, hvor andre ser affald, en n\u00f8glespiller for sund aldring og levetid og er, i samarbejde med Dr. Patrick Tonnard, begejstrede for at g\u00f8re denne kick-off til vores bidrag til videnskaben.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/da\/eksosomer-i-nanomedicin\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. 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