{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"exosomen-in-der-nanomedizin","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/de\/exosomes-in-nanomedicine\/","title":{"rendered":"Exosomen in der Nanomedizin"},"content":{"rendered":"

Der ber\u00fchmte Cousin.<\/strong><\/p>\n

Mesenchymale Stammzellen, als potentiellem therapeutischem Werkzeug, stellen derzeit einen Star im klinischen Feld dar. Isolierte Zellen werden dennoch als Biomedizin klassifiziert und fallen somit unter viele komplexe Regularien. Wir sind uns alle einig, dass mehr Medizin in unseren K\u00f6rpern und mehr Papierkram auf unseren Schreibtischen nicht zwangsl\u00e4ufig das ist, was wir mehr von der Welt sehen wollen. Was die Notwendigkeit einer alternativen zellfreien Behandlung aufzeigt.<\/p>\n

Recycling ist das neue Sexy.<\/strong><\/p>\n

Das Sprichwort sagt Ohne Schmerz kein Gewinn<\/em>... aber trotzdem die zus\u00e4tzliche Einnahme von Medikamenten (5 Tage vor der Stammzellentnahme aus dem Blut) zu vermeiden, die Zellen aus dem Knochenmark ins Blut verschieben, aber auch Grippesymptome verursachen, oder (unter Narkose) das Einf\u00fchren einer Nadel in Ihr hinteres Beckenknochen, scheint ein gro\u00dfer Gewinn f\u00fcr uns zu sein. Eine sehr reiche Quelle f\u00fcr mesenchymale Stammzellen mit einer vergleichsweise geringen Invasivit\u00e4t bei der Entnahme ist n\u00e4her als wir denken.<\/p>\n

Es ist die nachhaltige energetische Reserve eines menschlichen K\u00f6rpers \u2013 das Fettgewebe, das nun (als Nebenprodukt von Fettabsaugungen) als Bioabfall behandelt wird.<\/p>\n

Auch die kleinste Blase kann den Lauf der Zukunft ver\u00e4ndern.<\/strong><\/p>\n

Fettgewebe ist ein heterogenes Gewebe, das in zwei Fraktionen unterteilt werden kann: die Adipozyten (Fettzellen) und die stromavaskul\u00e4re Fraktion. Letztere besteht dann aus der extrazellul\u00e4ren Matrix, einer Gemeinschaft verschiedener Zellen (wie Lymphozyten, Monozyten, Fibroblasten, Stammzellen) und wird als Mediator der zellul\u00e4ren Kommunikation freigesetzt: das Sekretom, das aus Proteinen (wie Wachstumsfaktoren und Hormonen) und Vesikeln \u2013 Exosomen \u2013 besteht.<\/p>\n

J\u00fcngste Studien zeigten, dass die regenerative Kapazit\u00e4t (in Organen, Gehirn, Netzhaut und Gelenkknorpel) des Geheimnisses allein, ohne Stammzellen aus Fettgewebe oder andere Zellen, \u00e4hnlich der regenerativen Kapazit\u00e4t des gesamten Lipoaspirats ist, was offenbart, dass Exosomen wichtige Transporter von biologischen Peptiden, miRNA, Chemokinen, Zytokinen, Enzymen, immunregulatorischen, trophischen und Wachstumsfaktoren sind.<\/p>\n

Unser kostbares..<\/strong><\/p>\n

Ein Exosom ist ein kleines, einzellmembranumh\u00fclltes, sezerniertes Organell, das die gleiche Topologie wie seine Mutterzelle besitzt. Es hat das Potenzial, Zellen anzulocken und Differenzierung, Proliferation und Vaskularisierung anzuregen, die f\u00fcr die Geweberegeneration essentiell sind.<\/p>\n

Gl\u00fccklicherweise ist das gr\u00f6\u00dftenteils alles, woraus wir bestehen.<\/p>\n

Was springt f\u00fcr mich dabei raus, ein gesunder Mensch in den besten Jahren?<\/strong><\/p>\n

Unser gr\u00f6\u00dftes Organ \u2013 die Haut \u2013 durchl\u00e4uft einen st\u00e4ndigen Reifungsprozess und verliert gerade in diesem Moment an Vitalit\u00e4t oder weist, trotz jungen Alters, Verf\u00e4rbungen oder (nach Akne, Unf\u00e4llen oder chirurgischen Eingriffen entstandene) Narben oder schwer heilende Wunden auf.<\/p>\n

..und unsere Vision.<\/strong><\/p>\n

Die regenerative Aktivit\u00e4t von Exosomen, sowie Protokolle zu ihrer Isolierung, werden derzeit intensiv (zeit- und kostenaufw\u00e4ndig) erforscht und liefern vielversprechende Ergebnisse.<\/p>\n

Bis heute ist jedoch kein medizinisches Ger\u00e4t verf\u00fcgbar, um die Anzahl und Dimension von Exosomen zu isolieren und zu bewerten (unter Verwendung von Multi-Omics) und den Ursprung dieser extrazellul\u00e4ren Vesikel zu untersuchen (basierend auf einem Antigen-Assay), um sie in gut kontrollierten zellfreien, erschwinglichen Therapien einzusetzen, was die Motivation weckte, dies zu unserem Schwerpunkt zu machen.<\/p>\n

Daher sehen wir, wo andere Abfall sehen, einen Schl\u00fcsselakteur f\u00fcr gesundes Altern und Langlebigkeit und freuen uns, in Zusammenarbeit mit Dr. Patrick Tonnard diesen Auftakt zu unserem Beitrag zur Wissenschaft zu machen.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. 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