{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"exosomas-en-nanomedicina","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/es\/exosomes-in-nanomedicine\/","title":{"rendered":"Exosomas en nanomedicina"},"content":{"rendered":"

El famoso primo.<\/strong><\/p>\n

Las c\u00e9lulas madre mesenquimales, como una herramienta terap\u00e9utica potencial, son actualmente una estrella del campo cl\u00ednico. Las c\u00e9lulas aisladas, sin embargo, se clasifican como biomedicina y, como tales, est\u00e1n sujetas a muchas regulaciones complejas. Todos estamos de acuerdo en que m\u00e1s medicamentos en nuestros cuerpos y m\u00e1s tr\u00e1mites en nuestros escritorios no es necesariamente lo que queremos ver m\u00e1s en el mundo. Lo que pone de relieve la necesidad de un tratamiento alternativo sin c\u00e9lulas.<\/p>\n

Reciclar es lo nuevo sexy.<\/strong><\/p>\n

El dicho dice Sin dolor, no hay ganancia<\/em>... pero evitar tomar medicaci\u00f3n adicional (durante 5 d\u00edas antes de la recolecci\u00f3n de c\u00e9lulas madre de la sangre) que mueva las c\u00e9lulas de la m\u00e9dula \u00f3sea al torrente sangu\u00edneo pero que tambi\u00e9n resulte en s\u00edntomas parecidos a la gripe o (mientras se est\u00e1 bajo anestesia) que se introduzca una aguja en la parte posterior del hueso p\u00e9lvico parece una gran ventaja para nosotros. Una fuente muy rica de c\u00e9lulas madre mesenquimales con una invasividad de recolecci\u00f3n comparativamente baja est\u00e1 m\u00e1s cerca de lo que pensamos.<\/p>\n

Es la reserva energ\u00e9tica sostenible de un cuerpo humano \u2013 el tejido adiposo (grasa), que ahora (como subproducto de las liposucciones) se trata como un bio-residuo.<\/p>\n

Incluso la ves\u00edcula m\u00e1s peque\u00f1a puede cambiar el curso del futuro.<\/strong><\/p>\n

El tejido adiposo es un tejido heterog\u00e9neo que se puede dividir en dos fracciones: los adipocitos (c\u00e9lulas grasas) y la fracci\u00f3n vascular estromal. Esta \u00faltima consiste en la matriz extracelular, una amalgama de varias c\u00e9lulas (como linfocitos, monocitos, fibroblastos, c\u00e9lulas madre) y liberada como mediador de la comunicaci\u00f3n intercelular: el secretoma, que consiste en prote\u00ednas (como factores de crecimiento y hormonas) y ves\u00edculas, exomas.<\/p>\n

Estudios recientes mostraron que la capacidad regenerativa (en \u00f3rganos, cerebro, retina y cart\u00edlago articular) del secretoma solo, sin c\u00e9lulas madre derivadas de adipocitos ni ninguna otra c\u00e9lula, es similar a la capacidad regenerativa de todo el lipoaspirado, revelando que los exosomas son importantes transportadores de p\u00e9ptidos biol\u00f3gicos, miRNA, quimiocinas, citoquinas, enzimas y factores inmunorreguladores, tr\u00f3ficos y de crecimiento.<\/p>\n

Nuestro precioso..<\/strong><\/p>\n

Un exosoma es un org\u00e1nulo secretado peque\u00f1o y de membrana \u00fanica que tiene la misma topolog\u00eda que su c\u00e9lula madre. Tiene el potencial de atraer c\u00e9lulas y estimular la diferenciaci\u00f3n, la proliferaci\u00f3n y la vascularizaci\u00f3n, que son esenciales en la regeneraci\u00f3n de tejidos.<\/p>\n

Afortunadamente para nosotros, eso es en su mayor parte de lo que estamos hechos.<\/p>\n

\u00bfQu\u00e9 gano yo, una persona sana en mi mejor momento?<\/strong><\/p>\n

Nuestro \u00f3rgano m\u00e1s grande, la piel, experimenta un proceso de maduraci\u00f3n constante, perdiendo su vitalidad mientras hablamos o, en otro ejemplo, a pesar de su corta edad, muestra decoloraci\u00f3n o cicatrices (post-acn\u00e9, post-accidente o post-intervenci\u00f3n quir\u00fargica) o heridas de dif\u00edcil curaci\u00f3n.<\/p>\n

.y nuestra visi\u00f3n.<\/strong><\/p>\n

La actividad regenerativa de los exosomas, as\u00ed como los protocolos para aislarlos, se encuentran actualmente en estudio exhaustivo (que consume tiempo y dinero) y arrojan resultados prometedores.<\/p>\n

Hasta la fecha, sin embargo, no se dispone de ning\u00fan dispositivo m\u00e9dico para aislar y evaluar (con el uso de multi-\u00f3mica) el n\u00famero y la dimensi\u00f3n de los exosomas e investigar el origen de estas ves\u00edculas extracelulares (bas\u00e1ndose en un ensayo de ant\u00edgenos), para utilizarlos en terapias sin c\u00e9lulas bien controladas y asequibles, lo que inspir\u00f3 el impulso para convertirlo en nuestro enfoque.<\/p>\n

Por lo tanto, donde otros ven desperdicio, nosotros vemos un actor clave en el envejecimiento saludable y la longevidad y, en colaboraci\u00f3n con el Dr. Patrick Tonnard, estamos entusiasmados de hacer de este inicio nuestra contribuci\u00f3n a la ciencia.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/es\/exosomas-en-nanomedicina\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. 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