{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"esosomi-in-nanomedicina","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/it\/exosomes-in-nanomedicine\/","title":{"rendered":"Esosomi in nanomedicina"},"content":{"rendered":"

Il famoso cugino.<\/strong><\/p>\n

Le cellule staminali mesenchimali, come potenziale strumento terapeutico, sono attualmente una star del campo clinico. Le cellule isolate sono tuttavia classificate come biomedicina e come tali ricadono sotto molte complesse normative. Siamo tutti d'accordo che pi\u00f9 medicina nel nostro corpo e pi\u00f9 scartoffie sulle nostre scrivanie non \u00e8 necessariamente ci\u00f2 che vogliamo vedere di pi\u00f9 al mondo. Il che evidenzia la necessit\u00e0 di un trattamento alternativo privo di cellule.<\/p>\n

Il riciclo \u00e8 il nuovo sexy.<\/strong><\/p>\n

Il detto recita Senza dolore, nessun guadagno.<\/em>... pur evitando di assumere ulteriori farmaci (per 5 giorni prima della raccolta di cellule staminali dal sangue) che sposteranno le cellule dal midollo osseo al flusso sanguigno ma provocheranno anche sintomi simil-influenzali, o (sotto anestesia) l'inserimento di un ago nel retro dell'osso pelvico, sembra un grande beneficio per noi. Una fonte molto ricca di cellule staminali mesenchimali con una invasivit\u00e0 di raccolta comparativamente bassa \u00e8 pi\u00f9 vicina di quanto pensiamo.<\/p>\n

\u00c8 la riserva energetica sostenibile del corpo umano \u2013 il tessuto adiposo (grasso), che ora (come sottoprodotto della liposuzione) viene trattato come un bio-rifiuto.<\/p>\n

Anche la pi\u00f9 piccola vescicola pu\u00f2 cambiare il corso del futuro.<\/strong><\/p>\n

Il tessuto adiposo \u00e8 un tessuto eterogeneo che pu\u00f2 essere diviso in due frazioni: gli adipociti (cellule adipose) e la frazione vascolare stromale. Quest'ultima \u00e8 costituita dalla matrice extracellulare, una comunit\u00e0 di varie cellule (come linfociti, monociti, fibroblasti, cellule staminali) e rilasciata come mediatore della comunicazione intercellulare: il secretoma, costituito da proteine (come fattori di crescita e ormoni) e vescicole \u2013 esosomi.<\/p>\n

Recenti studi hanno dimostrato che la capacit\u00e0 rigenerativa (in organi, cervello, retina e cartilagine articolare) del solo secretoma, senza cellule staminali derivate dal tessuto adiposo o altre cellule, \u00e8 simile alla capacit\u00e0 rigenerativa dell'intero lipoaspirato, rivelando che le esosomi sono importanti trasportatori di peptidi biologici, miRNA, chemochine, citochine, enzimi, fattori immunomodulatori, trofici e di crescita.<\/p>\n

La nostra preziosa..<\/strong><\/p>\n

Un esosoma \u00e8 un piccolo organello secreto a singola membrana che ha la stessa topologia della sua cellula madre. Ha il potenziale di attrarre cellule e di stimolare la differenziazione, la proliferazione e la vascolarizzazione, che sono essenziali nella rigenerazione dei tessuti.<\/p>\n

Fortunatamente per noi, \u00e8 per lo pi\u00f9 di questo che siamo fatti.<\/p>\n

Cosa ci guadagno io, un individuo sano nel pieno delle mie forze?<\/strong><\/p>\n

Il nostro organo pi\u00f9 grande, la pelle, subisce un costante processo di maturazione, perdendo la sua vitalit\u00e0 mentre parliamo o, altro esempio, nonostante la giovane et\u00e0 mostrando discromie o cicatrici (post-acne, post-incidente o post-intervento chirurgico) o ferite difficili da rimarginare.<\/p>\n

.e la nostra visione.<\/strong><\/p>\n

L'attivit\u00e0 rigenerativa delle esosomi, cos\u00ec come i protocolli per isolarle, sono attualmente oggetto di studi approfonditi (che richiedono molto tempo e costi) e producono risultati promettenti.<\/p>\n

Ad oggi, tuttavia, non \u00e8 disponibile alcun dispositivo medico per isolare e valutare (con l'uso di multi-omiche) il numero e le dimensioni delle esosomi e per indagare l'origine di queste vescicole extracellulari (basandosi su un dosaggio antigenico), al fine di utilizzarle in terapie prive di cellule ben controllate e convenienti, il che ha ispirato la spinta a renderlo il nostro obiettivo.<\/p>\n

Pertanto, dove altri vedono spreco, noi vediamo un attore chiave dell'invecchiamento sano e della longevit\u00e0 e siamo, in collaborazione con il Dott. Patrick Tonnard, entusiasti di fare di questo lancio il nostro contributo alla scienza.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/it\/esosomi-in-nanomedicina\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. 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