{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"egzosomy-w-nanomedycynie","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/pl\/exosomes-in-nanomedicine\/","title":{"rendered":"Eksosomy w nanomedycynie"},"content":{"rendered":"

S\u0142ynny kuzyn.<\/strong><\/p>\n

Mezenchymalne kom\u00f3rki macierzyste, jako potencjalne narz\u0119dzie terapeutyczne, stanowi\u0105 obecnie gwiazd\u0119 dziedziny klinicznej. Izolowane kom\u00f3rki s\u0105 jednak klasyfikowane jako biomedycyna i jako takie podlegaj\u0105 wielu z\u0142o\u017conym regulacjom. Wszyscy zgadzamy si\u0119, \u017ce wi\u0119cej medycyny w naszych cia\u0142ach i wi\u0119cej papierkowej roboty na naszych biurkach to niekoniecznie to, czego chcemy widzie\u0107 wi\u0119cej na \u015bwiecie. Co wskazuje na potrzeb\u0119 alternatywnego leczenia bezkom\u00f3rkowego.<\/p>\n

Recykling jest teraz sexy.<\/strong><\/p>\n

M\u00f3wi si\u0119 Bez pracy nie ma ko\u0142aczy<\/em>... a jednak unikanie przyjmowania dodatkowych lek\u00f3w (przez 5 dni przed pobraniem kom\u00f3rek macierzystych z krwi), kt\u00f3re przemieszcza\u0142yby kom\u00f3rki ze szpiku kostnego do krwiobiegu, ale tak\u017ce powodowa\u0142yby objawy grypopodobne, lub (podczas znieczulenia) wprowadzanie ig\u0142y do ko\u015bci miednicznej wydaje si\u0119 dla nas sporym zyskiem. Bardzo bogate \u017ar\u00f3d\u0142o mezenchymalnych kom\u00f3rek macierzystych o stosunkowo niskiej inwazyjno\u015bci pobrania jest bli\u017cej ni\u017c nam si\u0119 wydaje.<\/p>\n

Tkanka t\u0142uszczowa, b\u0119d\u0105ca zr\u00f3wnowa\u017conym zapasem energetycznym ludzkiego organizmu, jest obecnie (jako produkt uboczny liposukcji) traktowana jako bio-odpad.<\/p>\n

Nawet najmniejsza ba\u0144ka mo\u017ce zmieni\u0107 bieg przysz\u0142o\u015bci.<\/strong><\/p>\n

Tkanka t\u0142uszczowa jest tkank\u0105 heterogenn\u0105, kt\u00f3r\u0105 mo\u017cna podzieli\u0107 na dwie frakcje: adypocyty (kom\u00f3rki t\u0142uszczowe) oraz frakcj\u0119 stromowo-naczyniow\u0105. Ta druga sk\u0142ada si\u0119 z macierzy pozakom\u00f3rkowej, zbioru r\u00f3\u017cnych kom\u00f3rek (takich jak limfocyty, monocyty, fibroblasty, kom\u00f3rki macierzyste) i uwalnianego jako mediator komunikacji mi\u0119dzykom\u00f3rkowej: sekretomu, sk\u0142adaj\u0105cego si\u0119 z bia\u0142ek (takich jak czynniki wzrostu i hormony) oraz p\u0119cherzyk\u00f3w \u2013 egzosom\u00f3w.<\/p>\n

Ostatnie badania wykaza\u0142y, \u017ce zdolno\u015b\u0107 regeneracyjna (w narz\u0105dach, m\u00f3zgu, siatk\u00f3wce i chrz\u0105stce stawowej) samego sekretomu, bez kom\u00f3rek macierzystych pochodzenia t\u0142uszczowego lub innych kom\u00f3rek, jest podobna do zdolno\u015bci regeneracyjnej ca\u0142ego lipoaspiratu, ujawniaj\u0105c, \u017ce egzosomy s\u0105 wa\u017cnymi transporterami peptyd\u00f3w biologicznych, miRNA, chemokin, cytokin, enzym\u00f3w, czynnik\u00f3w immunoregulacyjnych, troficznych i wzrostu.<\/p>\n

Nasz drogocenny..<\/strong><\/p>\n

Egzosom to ma\u0142y, jednob\u0142onowy, wydzielany organellum, kt\u00f3ry ma t\u0119 sam\u0105 topologi\u0119 co kom\u00f3rka macierzysta. Ma potencja\u0142 do przyci\u0105gania kom\u00f3rek i stymulowania r\u00f3\u017cnicowania, proliferacji i unaczynienia, kt\u00f3re s\u0105 niezb\u0119dne w regeneracji tkanek.<\/p>\n

Na szcz\u0119\u015bcie, to w wi\u0119kszo\u015bci wszystko, z czego jeste\u015bmy zbudowani.<\/p>\n

Co ja z tego b\u0119d\u0119 mia\u0142, zdrowa osoba w sile wieku?<\/strong><\/p>\n

Nasz najwi\u0119kszy organ \u2013 sk\u00f3ra \u2013 przechodzi sta\u0142y proces dojrzewania, trac\u0105c witalno\u015b\u0107 w miar\u0119 up\u0142ywu czasu, lub, w innym przyk\u0142adzie, pomimo m\u0142odego wieku wykazuj\u0105c przebarwienia lub blizny (potr\u0105dzikowe, pourazowe lub pooperacyjne) czy trudno goj\u0105ce si\u0119 rany.<\/p>\n

...i nasza wizja.<\/strong><\/p>\n

Aktywno\u015b\u0107 regeneracyjna egzosom\u00f3w, a tak\u017ce protoko\u0142y ich izolacji s\u0105 obecnie przedmiotem intensywnych (czasoch\u0142onnych i kosztownych) bada\u0144, kt\u00f3re przynosz\u0105 obiecuj\u0105ce rezultaty.<\/p>\n

Do tej pory jednak, nie jest dost\u0119pny \u017caden przyrz\u0105d medyczny do izolowania i oceny (za pomoc\u0105 technik multi-omicznych) liczby i wymiar\u00f3w egzoosom\u00f3w oraz do badania pochodzenia tych pozakom\u00f3rkowych p\u0119cherzyk\u00f3w (na podstawie testu antygenowego), aby wykorzysta\u0107 je w dobrze kontrolowanych, wolnych od kom\u00f3rek, niedrogich terapiach, co zainspirowa\u0142o nas do uczynienia tego naszym celem.<\/p>\n

Dlatego tam, gdzie inni widz\u0105 odpady, my widzimy kluczowego gracza w procesie zdrowego starzenia si\u0119 i d\u0142ugowieczno\u015bci i z zapa\u0142em, we wsp\u00f3\u0142pracy z dr. Patrickiem Tonnardem, pragniemy, aby to rozpocz\u0119cie by\u0142o naszym wk\u0142adem w nauk\u0119.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/pl\/egzosomy-w-nanomedycynie\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. 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