{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"exossomas-na-nanomedicina","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/pt\/exosomes-in-nanomedicine\/","title":{"rendered":"Exossomas na nanomedicina"},"content":{"rendered":"

O primo famoso.<\/strong><\/p>\n

As c\u00e9lulas estaminais mesenquimais, enquanto potencial ferramenta terap\u00eautica, s\u00e3o atualmente uma das grandes protagonistas no campo cl\u00ednico. No entanto, as c\u00e9lulas isoladas s\u00e3o classificadas como produtos biom\u00e9dicos e, como tal, est\u00e3o sujeitas a uma s\u00e9rie de regulamenta\u00e7\u00f5es complexas. Todos concordamos que mais medicamentos nos nossos corpos e mais papelada nas nossas secret\u00e1rias n\u00e3o s\u00e3o necessariamente o que queremos ver a aumentar no mundo. O que real\u00e7a a necessidade de um tratamento alternativo sem c\u00e9lulas.<\/p>\n

A reciclagem est\u00e1 na moda.<\/strong><\/p>\n

Diz-se que... Sem esfor\u00e7o, n\u00e3o h\u00e1 recompensa<\/em>... mas evitar tomar medica\u00e7\u00e3o adicional (durante 5 dias antes da recolha de c\u00e9lulas estaminais do sangue) que faz com que as c\u00e9lulas passem da medula \u00f3ssea para a corrente sangu\u00ednea, mas que tamb\u00e9m provoca sintomas semelhantes aos da gripe, ou (sob anestesia) ter de se submeter \u00e0 inser\u00e7\u00e3o de uma agulha no osso p\u00e9lvico posterior, parece-nos uma grande vantagem. Uma fonte muito rica de c\u00e9lulas estaminais mesenquimais, com um n\u00edvel de invasividade relativamente baixo na recolha, est\u00e1 mais perto do que pensamos.<\/p>\n

\u00c9 a reserva energ\u00e9tica sustent\u00e1vel do corpo humano \u2013 o tecido adiposo (gordura) \u2013, que atualmente (como subproduto das lipoaspira\u00e7\u00f5es) est\u00e1 a ser tratado como res\u00edduo biol\u00f3gico.<\/p>\n

At\u00e9 mesmo a mais pequena ves\u00edcula pode alterar o rumo do futuro.<\/strong><\/p>\n

O tecido adiposo \u00e9 um tecido heterog\u00e9neo que pode ser dividido em duas fra\u00e7\u00f5es: os adip\u00f3citos (c\u00e9lulas adiposas) e a fra\u00e7\u00e3o estromal vascular. Esta \u00faltima \u00e9 constitu\u00edda pela matriz extracelular, um conjunto de v\u00e1rias c\u00e9lulas (como linf\u00f3citos, mon\u00f3citos, fibroblastos e c\u00e9lulas estaminais) e \u00e9 libertada como mediador da comunica\u00e7\u00e3o intercelular: o secretoma, composto por prote\u00ednas (tais como fatores de crescimento e hormonas) e ves\u00edculas \u2013 os exossomas.<\/p>\n

Estudos recentes demonstraram que a capacidade regenerativa (em \u00f3rg\u00e3os, c\u00e9rebro, retina e cartilagem articular) do secretoma por si s\u00f3, sem c\u00e9lulas estaminais derivadas do tecido adiposo ou quaisquer outras c\u00e9lulas, \u00e9 semelhante \u00e0 capacidade regenerativa do lipoaspirado na sua totalidade, revelando que os exossomas s\u00e3o importantes transportadores de pept\u00eddeos biol\u00f3gicos, miRNA, quimiocinas, citocinas, enzimas, fatores imunorreguladores, tr\u00f3ficos e de crescimento.<\/p>\n

O nosso querido...<\/strong><\/p>\n

Um exossoma \u00e9 uma pequena organela secretada, de membrana \u00fanica, que possui a mesma topologia que a sua c\u00e9lula-m\u00e3e. Tem o potencial de atrair c\u00e9lulas e de estimular a diferencia\u00e7\u00e3o, a prolifera\u00e7\u00e3o e a vasculariza\u00e7\u00e3o, processos essenciais na regenera\u00e7\u00e3o dos tecidos.<\/p>\n

Felizmente para n\u00f3s, \u00e9 basicamente disso que somos feitos.<\/p>\n

O que \u00e9 que eu, uma pessoa saud\u00e1vel no auge da minha vida, ganho com isso?<\/strong><\/p>\n

O nosso maior \u00f3rg\u00e3o \u2013 a pele \u2013 passa por um processo constante de matura\u00e7\u00e3o, perdendo a sua vitalidade neste preciso momento ou, por exemplo, apesar da tenra idade, apresentando descolora\u00e7\u00e3o ou cicatrizes (p\u00f3s-acne, p\u00f3s-acidente ou p\u00f3s-interven\u00e7\u00e3o cir\u00fargica) ou feridas de dif\u00edcil cicatriza\u00e7\u00e3o.<\/p>\n

... e a nossa vis\u00e3o.<\/strong><\/p>\n

A atividade regenerativa dos exossomas, bem como os protocolos para os isolar, est\u00e3o atualmente a ser alvo de estudos exaustivos (demorados e dispendiosos) e apresentam resultados promissores.<\/p>\n

At\u00e9 \u00e0 data, no entanto, n\u00e3o existe nenhum dispositivo m\u00e9dico dispon\u00edvel para isolar e avaliar (atrav\u00e9s da utiliza\u00e7\u00e3o de abordagens multi-\u00f3micas) o n\u00famero e as dimens\u00f5es dos exossomas, nem para investigar a origem destas ves\u00edculas extracelulares (com base num ensaio de antig\u00e9nios), com vista \u00e0 sua utiliza\u00e7\u00e3o em terapias sem c\u00e9lulas, bem controladas e acess\u00edveis, o que nos levou a fazer disso o nosso foco.<\/p>\n

Assim, enquanto outros v\u00eaem res\u00edduos, n\u00f3s vemos um elemento fundamental para um envelhecimento saud\u00e1vel e para a longevidade e, em colabora\u00e7\u00e3o com o Dr. Patrick Tonnard, estamos entusiasmados por fazer deste lan\u00e7amento a nossa contribui\u00e7\u00e3o para a ci\u00eancia.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/pt\/exossomas-na-nanomedicina\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. 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