{"id":2692,"date":"2022-10-20T18:00:27","date_gmt":"2022-10-20T17:00:27","guid":{"rendered":"https:\/\/cosmogroup.eu\/?p=2692"},"modified":"2024-11-19T13:59:21","modified_gmt":"2024-11-19T12:59:21","slug":"exosomer-inom-nanomedicin","status":"publish","type":"post","link":"https:\/\/cosmogroup.eu\/sv\/exosomes-in-nanomedicine\/","title":{"rendered":"Exosomer inom nanomedicin"},"content":{"rendered":"

Den ber\u00f6mda kusinen.<\/strong><\/p>\n

Mesenchymala stamceller, som ett potentiellt terapeutiskt verktyg, \u00e4r f\u00f6r n\u00e4rvarande en stor stj\u00e4rna inom det kliniska omr\u00e5det. De isolerade cellerna klassificeras dock som biomedicin och omfattas d\u00e4rf\u00f6r av m\u00e5nga komplexa best\u00e4mmelser. Vi \u00e4r alla \u00f6verens om att mer medicin i v\u00e5ra kroppar och mer pappersarbete p\u00e5 v\u00e5ra skrivbord inte n\u00f6dv\u00e4ndigtvis \u00e4r n\u00e5got vi vill se mer av i v\u00e4rlden. Detta understryker behovet av en alternativ cellfri behandling.<\/p>\n

\u00c5tervinning \u00e4r det nya sexiga.<\/strong><\/p>\n

Det s\u00e4gs att Ingen sm\u00e4rta, ingen vinst<\/em>... men att slippa ta ytterligare medicin (under 5 dagar f\u00f6re stamcellsuttaget fr\u00e5n blodet) som f\u00f6rflyttar celler fr\u00e5n benm\u00e4rgen till blodomloppet men ocks\u00e5 ger influensaliknande symtom, eller (under narkos) att f\u00e5 en n\u00e5l insatt i det bakre b\u00e4ckenbenet, verkar vara en stor f\u00f6rdel f\u00f6r oss. En mycket rik k\u00e4lla till mesenkymala stamceller med en relativt l\u00e5g invasivitet vid insamlingen finns n\u00e4rmare \u00e4n vi tror.<\/p>\n

Det \u00e4r m\u00e4nniskokroppens h\u00e5llbara energireserv \u2013 fettv\u00e4vnaden \u2013 som numera (som en biprodukt av fettsugningar) behandlas som bioavfall.<\/p>\n

\u00c4ven den minsta vesikeln kan f\u00f6r\u00e4ndra framtidens g\u00e5ng.<\/strong><\/p>\n

Fettv\u00e4vnad \u00e4r en heterogen v\u00e4vnad som kan delas in i tv\u00e5 fraktioner: adipocyterna (fettcellerna) och den stromala vaskul\u00e4ra fraktionen. Den senare best\u00e5r i sin tur av den extracellul\u00e4ra matrisen, en sammans\u00e4ttning av olika celler (s\u00e5som lymfocyter, monocyter, fibroblaster och stamceller) samt \u00e4mnen som uts\u00f6ndras som mediatorer f\u00f6r intercellul\u00e4r kommunikation: sekretomet, best\u00e5ende av proteiner (s\u00e5som tillv\u00e4xtfaktorer och hormoner) och vesiklar \u2013 exosomer.<\/p>\n

Nya studier har visat att regenereringsf\u00f6rm\u00e5gan (i organ, hj\u00e4rna, n\u00e4thinnan och ledbrosk) hos enbart sekretomet, utan stamceller fr\u00e5n fettv\u00e4vnad eller n\u00e5gra andra celler, \u00e4r likv\u00e4rdig med regenereringsf\u00f6rm\u00e5gan hos hela fettv\u00e4vnadsaspiratet, vilket visar att exosomer \u00e4r viktiga transport\u00f6rer av biologiska peptider, miRNA, kemokiner, cytokiner, enzymer, immunreglerande, trofiska och tillv\u00e4xtfaktorer.<\/p>\n

V\u00e5r \u00e4lskade...<\/strong><\/p>\n

Ett exosom \u00e4r en liten, enkelv\u00e4ggig, uts\u00f6ndrad organell som har samma topologi som sin modercell. Det har f\u00f6rm\u00e5gan att dra till sig celler och stimulera differentiering, proliferation och vaskularisering, vilket \u00e4r avg\u00f6rande f\u00f6r v\u00e4vnadsregenerering.<\/p>\n

Lyckligtvis f\u00f6r oss \u00e4r det i stort sett allt som vi best\u00e5r av.<\/p>\n

Vad har jag, som \u00e4r en frisk person i mina b\u00e4sta \u00e5r, att vinna p\u00e5 det?<\/strong><\/p>\n

V\u00e5rt st\u00f6rsta organ \u2013 huden \u2013 genomg\u00e5r en st\u00e4ndig mognadsprocess och f\u00f6rlorar sin vitalitet just nu, eller, f\u00f6r att ta ett annat exempel, uppvisar trots ung \u00e5lder missf\u00e4rgningar eller \u00e4rr (efter akne, olycka eller kirurgiskt ingrepp) eller sv\u00e5rl\u00e4kta s\u00e5r.<\/p>\n

..och v\u00e5r vision.<\/strong><\/p>\n

Exosomernas regenerativa verkan, liksom metoderna f\u00f6r att isolera dem, \u00e4r f\u00f6r n\u00e4rvarande f\u00f6rem\u00e5l f\u00f6r omfattande (tids- och kostnadskr\u00e4vande) forskning och ger lovande resultat.<\/p>\n

Hittills finns det dock ingen medicinteknisk produkt som g\u00f6r det m\u00f6jligt att isolera och utv\u00e4rdera (med hj\u00e4lp av multi-omik) antalet och storleken p\u00e5 exosomer samt att unders\u00f6ka ursprunget till dessa extracellul\u00e4ra vesiklar (med utg\u00e5ngspunkt i en antigenanalys), i syfte att anv\u00e4nda dem i v\u00e4lkontrollerade, cellfria och kostnadseffektiva behandlingar \u2013 vilket har inspirerat oss att g\u00f6ra detta till v\u00e5rt fokusomr\u00e5de.<\/p>\n

D\u00e4rf\u00f6r ser vi, d\u00e4r andra ser avfall, en viktig faktor f\u00f6r ett h\u00e4lsosamt \u00e5ldrande och ett l\u00e5ngt liv, och vi ser fram emot att i samarbete med dr Patrick Tonnard g\u00f6ra denna uppstart till v\u00e5rt bidrag till vetenskapen.<\/p>","protected":false},"excerpt":{"rendered":"

The famous cousin. Mesenchymal stem cells, as a potential therapeutic tool, are currently a star of the clinical field. Isolated cells are nevertheless classified as biomedicine and as such fall under many complex regulations. We all agree that more medicine in our bodies and more paperwork on our desks is not necessarily what we want […]<\/p>\n","protected":false},"author":12,"featured_media":7109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-development"],"yoast_head":"\nExosomes in nanomedicine - Cosmogroup<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cosmogroup.eu\/sv\/exosomer-inom-nanomedicin\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exosomes in nanomedicine\" \/>\n<meta property=\"og:description\" content=\"The famous cousin. 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